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Selected COMPARE Publications

Ast J, et al,  (2020). Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics. Nat Commun.  doi: 10.1038/s41467-020-14309-w

Wilson DH, Bates DO, et al (2020). Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors. Nat Commun. doi: 10.1038/s41467-020-14283-3

Budnik I, Brill A, (2018). Immune Factors in Deep Vein Thrombosis Initiation. Trends Immunol. 39: 610-623

Calebiro D, Sungkaworn T, (2018). Single-Molecule Imaging of GPCR Interactions. Trends Pharmacol Sci Review. 39: 109-122

Deen J, Wang S, Van Snick S, Leen V, Janssen K, Hofkens J, Neely RK, (2018). A general strategy for direct, enzyme-catalyzed conjugation of functional compounds to DNA. Nucleic Acids Res. 46: e64.

Fehrentz T, Huber FME, Hartrampf N, Bruegmann T, Frank JA, Fine NHF, Malan D, Danzl JG, Tikhonov DB, Sumser M, Sasse P, Hodson DJ, Zhorov BS, Klöcker N, Trauner D, (2018). Optical control of L-type Ca2+ channels using a diltiazem photoswitch. Nat Chem Biol. 14: 764-767

Frank JA, Broichhagen J, Yushchenko DA, Trauner D, Schultz C, Hodson DJ, (2018). Optical Tools for understanding the complexity of beta cell signalling and insulin release. Nature Rev End. 14: 721-737

Hall ML and Canals M, (2018). Genetically Encoded FRET Biosensors to Illuminate Compartmentalised GPCR Signalling. Trends Pharmacol Sci Review. 39: 148-157

Hill SJ, Watson SP, (2018). Fluorescence approaches unravel spatial and temporal aspects of GPCR organisation, location and intracellular signalling. Trends Pharmacol Sci Review. 39: 91-92

Podewin T, Ast J, Broichhagen J, Fine N, Nasteska D,Leippe P, Gailer M, Buenaventura T, Jones B, Baneres, JL, Marie J, Trauner D, Hoffmann-Röder A, Hodson DJ, (2018).  Conditional and reversible activation of class A and B G protein-coupled receptors using tethered pharmacology. ACS Central Sci. 5: 166-179

Shrine N, Guyatt AL, Erzurumluoglu AM, Jackson VE, Hall IP et al, (2019). New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nat Genet. 51: 1067

Stoddart LA, Kilpatrick LE, Hill SJ, (2018). NanoBRET approaches to study ligand binding to GPCRs and RTKs.  Trends Pharmacol. Sci Review.  39: 136-147

Sykes DA, Lane JR, Szabo M, Capuano B, Javitch JA, Charlton SJ, (2018). Reply to 'Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects'. Nat Commun. 3: 3568

Tommasone S, Allabush F, Tagger YK, Norman J, Köpf M, Tucker JHR, Mendes PM, (2019). The challenges of glycan recognition with natural and artificial receptors. Chem Soc Rev. 2019 Sep 25. doi: 10.1039/c8cs00768c. [Epub ahead of print]

van Meer BJ, Krotenberg A, Sala L, Davis RP, Eschenhagen T, Denning C, Tertoolen LGJ, Mummery CL, (2019). Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes. Nat Commun. 10 : 4325

Zyryanova AF, Weis F, Faille A, Alard AA, Crespillo-Casado A, Sekine Y, Harding HP, Allen F, Parts L, Fromont C, Fischer PM, Warren AJ, Ron D, (2018). Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B. Science.  359: 1533-1536

Beristain-Covarrubias N, Perez-Toledo M, Flores-Langarica A, Zuidscherwoude M, Hitchcock JR, Channell WM, King LDW, Thomas MR, Henderson IR, Rayes J, Watson SP, Cunningham AF, (2018). Salmonella-induced thrombi in mice develop asynchronously in the spleen 1 and liver and are not effective bacterial traps. Blood.  133 : 600-604

Calebiro D, Jobin ML, (2019). Hot spots for GPCR signaling: lessons from single-molecule microscopy. Curr Opin Cell Biol. 57 : 57-63

Canals M, Poole DP, Veldhuis NA, Schmidt BL, Bunnett NW, (2019). G Protein-Coupled Receptors are Dynamic Regulators of Digestion and Targets for Digestive Diseases. Gastroenterology.  1456: 1600-1616

Lupino L, Perry T, Margielewska S, Hollows R, Ibrahim M, Care M, Allegood J, Tooze R, Sabbadini R, Reynolds G, Bicknell R, Rudzki Z, Lin Hock Y, Zanetto U, Wei W, Simmons W, Spiegel S, Woodman CBJ, Rowe M, Vrzalikova K, Murray PG, (2019). Sphingosine-1-phosphate signalling drives an angiogenic transcriptional programme in diffuse large B cell lymphoma. Leukemia. doi: 10.1038/s41375-019-0478-9. [Epub ahead of print] 

Mayer D, Damberger FF, Samarasimhareddy M, Feldmueller M, Vuckovic Z, Flock T, Bauer B, Mutt E, Zosel F, Allain FHT, Standfuss J, Schertler GFX, Deupi X, Sommer ME, Hurevich M, Friedler A, Veprintsev DB,(2019). Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation. Nat Commun. 10 : 1261

Rayes J, Watson SP, Nueswandt B, (2019).  Functional significance of the platelet immune receptors GPVI and CLEC-2. J Clin Invest.  129: 12-23

Shrine N, Guyatt AL, Erzurumluoglu AM, Jackson VE Hall IP et al, (2019). New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nat Genet. doi: 10.1038/s41588-019-0438-3. [Epub ahead of print]

Wand NO, Smith DA, Wilkinson AA, Rushton AE, Busby SJW, Styles IB, Neely RK, (2019). DNA barcodes for rapid, whole genome, single-molecule analyses. Nucleic Acids Res.  pii: gkz212. doi: 10.1093/nar/gkz212. [Epub ahead of print]

Hollinshead KER, Munford H, Eales K, Bardella C, Li C, Escribano-Gonzalez C, Nonnenmacher Y, Thakker A, Murren R, Cuozzo F, Ye D, Laurenti G, Zhu W, Hiller K, Hodson DJ, Hua W, Tomlinson I, Ludwig C, Mao Y, Tennant, DA, (2018). Oncogenic IDH1 mutations promote enhanced proline synthesis through PYCR1 to support the maintenance of mitochondrial redox homeostasis. Cell Rep.

Geer MJ, van Geffen JP, Gopalasingam P, Vögtle T, Smith C, Heising S, Kuijpers MJE, Tullemans BME, Jarvis GE, Jeeves M, Overduin M, Heemskerk JWM, Mazharian A, Senis YA, (2018).  Uncoupling of the ITIM receptor G6b-B from the tyrosine phosphatases Shp1 and Shp2 disrupts platelet homeostasis in mice. Blood. doi: 10.1182/blood-2017-10-802975. [Epub ahead of print]

Hofmann I, Geer MJ, Vögtle T, Crispin A,  Campagna DR, Barr A, Calicchio ML, Heising S, van Geffen JP, Kuijper MJE, Heemskerk JWM, Schmitz-Abe K, Obeng EA, Douglas M, Freson K, Pondarré C, Favier R, Markianos K, Turro E, Ouwehand WH, Mazharian A, Fleming MD, Senis YA, (2018). Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice. Blood. doi: 10.1182/blood-2017-08-802769. [Epub ahead of print]

Mori J, Nagy Z, Di Nunzio G, Smith CW, Geer MJ, Al Ghaithi R, van Geffen JP, Heising S, Boothman L, Tullemans BME, Correia JN,  Tee L, Kuijpers MJE, Harrison P, Heemskerk JWM, Jarvis GE, Tarakhovsky A, Weiss A, Mazharian A, Senis YA, (2018).  Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148. Blood. 131: 1122-1144

Benninger RKP and Hodson DJ, (2018). New understanding of beta cell heterogeneity and in-situ islet function. Diabetes. 67:537-547

Beazley-Long N, Moss CE, Ashby WR, Bestall SM, Almahasneh F, Durrant AM, Benest AV, Blackley Z, Ballmer-Hofer K, Hirashima M, Hulse RP, Bates DO, Donaldson LF, (2018). VEGFR2 promotes central endothelial activation and the spread of pain in inflammatory arthritis. Brain, Behav & Imm (online)

Briddon SJ, Kilpatrick LE, Hill SJ, (2018). Studying GCPR pharmacology in membrane microdomains:  Fluorescence Correlation Spectroscopy comes of age.  Trends Pharmacol. Sci. (Review)

Rayes J, Lax S, Wichaiyo S, Watson SK,  Di Y, Lombard S, Grygielska B, Smith SW, Skordilis K, Watson SP, (2017). The podoplanin-CLEC-2 axis inhibits inflammation in sepsis. Nat Commun 8: 2239

Sungkaworn T, Jobin ML, Burnecki K, Weron A, Lohse MJ, Calebiro D, (2017). Single-molecule imaging reveals receptor–G protein interactions at cell surface hot spots. Nature. 550: 543-547

Sykes DA, Moore H, Stott L, Holliday N, Javitch JA, Lane JR, Charlton SJ, (2017). Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors. Nat Commun. 8: 763

Ponomaryov T, Payne H, Fabrtz L, Wagner DD and Brill A, (2017). Mast cells granular contents are crucial for deep vein thrombosis in mice. Circ Res. 121: 941:950

Matthey M, Roberts R, Seidinger A, Simon A, Schroder R, Kuschak M, Annala S, Konig GM, Muller CE, Hall IP, Kostenis E, Fleischmann BK, Wenzel D, (2017). Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma. Sci Transl Med.  9 : 407

Botfield HF, Uldall MS, Westgate CSJ, Mitchell J, Hagen SM, Gonzalez A-M, Hodson DJ, Jensen RH, Sinclair AJ, (2017). A glucagon-like peptide-1 receptor agonist reduces intracranial pressure in a rat model of hydrocephalus. Sci Transl Med. 23: 9 (404) 

Hobbs BD, de Jong K, Lamontagne M, Bossé Y, Shrine N, Artigas MS, Wain LV, Hall IP et al, (2017). Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat Genetics. 49: 426-432

Johnston NR, Mitchell RK, Haythorne E, Paiva Pessoa M, Semplici F, Ferrer J, Piemonti L, Marchetti P, Bugliani M, Bosco D, Berishvili E, Duncanson P, Watkinson, M, Broichhagen J, Trauner D, Rutter GA, Hodson DJ, (2016). Beta cell hubs dictate pancreatic islet responses to glucose. Cell Metab. 24: 389-401. 

Frank JA, Yushchenko D, Hodson DJ, Lipstein N, Nagpal J, Rutter GA, Rhee J-S, Gottschalk A, Brose N, Schultz C, Trauner D, (2016). Photoswitchable diacylglycerols enable optical control of protein kinase C. Nat Chem Biol. 12: 755-62. 

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The University of Nottingham
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