Selected COMPARE Publications
Soave M, Stoddart LA, White CW, Kilpatrick LE, Goulding J, Briddon SJ, Hill SJ (2021). Detection of genome-edited and endogenously expressed G protein-coupled receptors. FEBS J. 2021 Jan 28. https://doi.org/10.1111/febs.15729.
Stoddart LA, Kindon ND, Otun O, Harwood CR, Patera F, Veprintsev DB, Woolard J, Briddon SJ, Franks HA, Hill SJ, Kellam B (2020). Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells. Commun Biol. 2020 Nov 27;3(1):722. https://doi.org/10.1038/s42003-020-01451-w.
Kondrashov A, Mohd Yusof NAN, Hasan A, Goulding J, Kodagoda T, Hoang DM, Vo NTN, Melarangi T, Dolatshad N, Gorelik J, Hill SJ, Harding SE, Denning C (2020). CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of β2AR in isogenic hPSC-derived cardiomyocytes. Mol Ther Methods Clin Dev. 2020 Oct 27 https://doi.org/10.1016/j.omtm.2020.10.019.
Soave M, Goulding J, Markus R, Hill SJ, Stoddart LA (2020). Application of Fluorescent Purinoceptor Antagonists for Bioluminescence Resonance Energy Transfer Assays and Fluorescent Microscopy. Methods Mol Biol. 2020; https://doi.org/10.1007/978-1-4939-9717-6_12.
Bourne JH, Colicchia M, Di Y, Martin E, Slater A, Roumenina LT, Dimitrov JD, Watson SP, Rayes J, (2020). Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2. Haematologica.
doi: 10.3324/haematol.2020.246488.
Hodson DJ, Rorsman P, (2020). A Variation on the Theme: SGLT2 Inhibition and Glucagon Secretion in Human Islets. Diabetes. 69 : 864-866. doi: 10.2337/dbi19-0035
Koo CZ, Harrison N, Noy PJ, Szyroka J, Matthews AL, Hsia HE, Müller SA, Tüshaus J, Goulding J, Willis K, Apicella C, Cragoe B, Davis E, Keles M, Malinova A, McFarlane TA, Morrison PR, Nguyen HTH, Sykes MC, Ahmed H, Di Maio A, Seipold L, Saftig P, Cull E, Pliotas C, Rubinstein E, Poulter NS, Briddon SJ, Holliday ND, Lichtenthaler SF, Tomlinson MG (2020). The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex. J Biol Chem. 2020 Sep 4. https://doi.org/10.1074/jbc.RA120.012601.
Makarova M, Owen DM, (2020). Asymmetry across the membrane. Nat Chem Biol. 2020 May 4.
doi: 10.1038/s41589-020-0545-6.
Richardson R, Groenen M, Liu M, Mountford SJ, Briddon SJ, Holliday ND, Thompson PE, (2020). Heterodimeric analogues of the potent Y1R antagonist 1229U91, lacking one of the pharmacophoric C-terminal structures, retain potent Y1R affinity and show improved selectivity over Y4R. J Med Chem. 2020 May 4.
doi: 10.1021/acs.jmedchem.0c00027.
Pickford P, Lucey M, Fang Z, Bitsi S, de la Serna JB, Broichhagen J, Hodson DJ, Minnion J, Rutter GA, Bloom SR, Tomas A, Jones B, (2020). Signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide. Br J Pharmacol. doi: 10.1111/bph.15134
Grime RL, Goulding J, Uddin R, Stoddart LA, Hill SJ, Poyner DR, Briddon SJ, Wheatley M, (2020). Single molecule binding of a ligand to a G-protein-coupled receptor in real time using fluorescence correlation spectroscopy, rendered possible by nano-encapsulation in styrene maleic acid lipid particles. Nanoscale.
doi: 10.1039/d0nr01060j
Kemkem Y, Nasteska D, de Bray A, Bargi-Souza P, Peliciari-Garcia RA, Guillou A, Mollard P, Hodson DJ, Schaeffer M, (2020). Maternal Hypothyroidism in Mice Influences Glucose Metabolism in Adult Offspring. Diabetologia, doi: 10.1007/s00125-020-05172-x. Online ahead of print.
Chauhan A, Sheriff L, Hussain MT, Webb GJ, Patten DA, Shepherd EL, Shaw R, Weston CJ, Haldar D, Bourke S, Bhandari R, Watson S, Adams DH, Watson SP, Lalor PF, (2020). The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure. Nat Commun. 11 : 1939.
doi: 10.1038/s41467-020-15584-3
Bourne JH, Colicchia M, Di Y, Martin E, Slater A, Roumenina LT, Dimitrov JD, Watson SP, Rayes J, (2020). Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2. Haematologica.
doi: 10.3324/haematol.2020.246488. [Epub ahead of print]
Gillis A, Gondin AB, Kliewer A, Sanchez J, Lim HD, Alamein C, Manandhar P, Santiago M, Fritzwanker S, Schmiedel F, Katte TA, Reekie T, Grimsey NL, Kassiou M, Kellam B, Krasel C, Halls M, Connor M, Lane JR, Schulz S, Christie MJ, Canals M, (2020). Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists. Sci Signal. 31 : 13(625). doi: 10.1126/scisignal.aaz3140
Williamson DJ, Burn GL, Simoncelli S, Griffié J, Peters R, Davis DM, Owen DM, (2020). Machine learning for cluster analysis of localization microscopy data. Nat Commun. doi: 10.1038/s41467-020-15293-x
Drakopoulos A, Koszegi Z, Lanoiselée Y, Hübner H, Gmeiner P, Calebiro D, Decker M, (2020). Investigation of Inactive-State κ Opioid Receptor Homodimerization via Single-Molecule Microscopy Using New Antagonistic Fluorescent Probes. J Med Chem. doi: 10.1021/acs.jmedchem.9b02011. [Epub ahead of print]
Bradley SJ, Molloy C, Valuskova P, Dwomoh L, Scarpa M, Rossi M, Finlayson L, Svensson KA, Chernet E, Barth VN, Gherbi K, Sykes DA, Wilson CA, Mistry R, Sexton PM, Christopoulos A, Mogg AJ, Rosethorne EM, Sakata S, John Challiss RA, Broad LM, Tobin AB, (2020). Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs. Nat Chem Biol. doi: 10.1038/s41589-019-0453-9. Epub 2020 Feb 20.
Comeo E, Kindon ND, Soave M, Stoddart LA, Kilpatrick LE, Scammells PJ, Hill SJ, Kellam B, (2020). Subtype-Selective Fluorescent Ligands as Pharmacological Research Tools for the Human Adenosine A2A Receptor. J Med Chem. 2020 Jan 9. doi: 10.1021/acs.jmedchem.9b01856. [Epub ahead of print]
Nicolson PLR, Nock SH, Hinds J, Garcia-Quintanilla L, Smith CW, Campos J, Brill A, Pike JA, Khan AO, Poulter NS, Kavanagh DM, Watson S, Watson CN, Clifford H, Huissoon AP, Pollitt AY, Eble JA, Pratt G, Watson SP, Hughes CE, (2020). Low dose Btk inhibitors selectively block platelet activation by CLEC-2. Haematologica.
doi: 10.3324/haematol.2019.218545. [Epub ahead of print]
White CW, Caspar B, Vanyai HK, Pfleger KDG, Hill SJ, (2020). CRISPR-Mediated Protein Tagging with Nanoluciferase to Investigate Native Chemokine Receptor Function and Conformational Changes. Cell Chem Biol. doi: 10.1016/j.chembiol.2020.01.010. [Epub ahead of print]
Ast J, et al, (2020). Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics. Nat Commun. doi: 10.1038/s41467-020-14309-w
Wilson DH, Bates DO, et al (2020). Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors. Nat Commun. doi: 10.1038/s41467-020-14283-3
Budnik I, Brill A, (2018). Immune Factors in Deep Vein Thrombosis Initiation. Trends Immunol. 39: 610-623
Calebiro D, Sungkaworn T, (2018). Single-Molecule Imaging of GPCR Interactions. Trends Pharmacol Sci Review. 39: 109-122
Deen J, Wang S, Van Snick S, Leen V, Janssen K, Hofkens J, Neely RK, (2018). A general strategy for direct, enzyme-catalyzed conjugation of functional compounds to DNA. Nucleic Acids Res. 46: e64.
Fehrentz T, Huber FME, Hartrampf N, Bruegmann T, Frank JA, Fine NHF, Malan D, Danzl JG, Tikhonov DB, Sumser M, Sasse P, Hodson DJ, Zhorov BS, Klöcker N, Trauner D, (2018). Optical control of L-type Ca2+ channels using a diltiazem photoswitch. Nat Chem Biol. 14: 764-767
Frank JA, Broichhagen J, Yushchenko DA, Trauner D, Schultz C, Hodson DJ, (2018). Optical Tools for understanding the complexity of beta cell signalling and insulin release. Nature Rev End. 14: 721-737
Hall ML and Canals M, (2018). Genetically Encoded FRET Biosensors to Illuminate Compartmentalised GPCR Signalling. Trends Pharmacol Sci Review. 39: 148-157
Hill SJ, Watson SP, (2018). Fluorescence approaches unravel spatial and temporal aspects of GPCR organisation, location and intracellular signalling. Trends Pharmacol Sci Review. 39: 91-92
Podewin T, Ast J, Broichhagen J, Fine N, Nasteska D,Leippe P, Gailer M, Buenaventura T, Jones B, Baneres, JL, Marie J, Trauner D, Hoffmann-Röder A, Hodson DJ, (2018). Conditional and reversible activation of class A and B G protein-coupled receptors using tethered pharmacology. ACS Central Sci. 5: 166-179
Shrine N, Guyatt AL, Erzurumluoglu AM, Jackson VE, Hall IP et al, (2019). New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nat Genet. 51: 1067
Stoddart LA, Kilpatrick LE, Hill SJ, (2018). NanoBRET approaches to study ligand binding to GPCRs and RTKs. Trends Pharmacol. Sci Review. 39: 136-147
Sykes DA, Lane JR, Szabo M, Capuano B, Javitch JA, Charlton SJ, (2018). Reply to 'Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects'. Nat Commun. 3: 3568
Tommasone S, Allabush F, Tagger YK, Norman J, Köpf M, Tucker JHR, Mendes PM, (2019). The challenges of glycan recognition with natural and artificial receptors. Chem Soc Rev. 2019 Sep 25. doi: 10.1039/c8cs00768c. [Epub ahead of print]
van Meer BJ, Krotenberg A, Sala L, Davis RP, Eschenhagen T, Denning C, Tertoolen LGJ, Mummery CL, (2019). Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes. Nat Commun. 10 : 4325
Zyryanova AF, Weis F, Faille A, Alard AA, Crespillo-Casado A, Sekine Y, Harding HP, Allen F, Parts L, Fromont C, Fischer PM, Warren AJ, Ron D, (2018). Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B. Science. 359: 1533-1536
Beristain-Covarrubias N, Perez-Toledo M, Flores-Langarica A, Zuidscherwoude M, Hitchcock JR, Channell WM, King LDW, Thomas MR, Henderson IR, Rayes J, Watson SP, Cunningham AF, (2018). Salmonella-induced thrombi in mice develop asynchronously in the spleen 1 and liver and are not effective bacterial traps. Blood. 133 : 600-604
Calebiro D, Jobin ML, (2019). Hot spots for GPCR signaling: lessons from single-molecule microscopy. Curr Opin Cell Biol. 57 : 57-63
Canals M, Poole DP, Veldhuis NA, Schmidt BL, Bunnett NW, (2019). G Protein-Coupled Receptors are Dynamic Regulators of Digestion and Targets for Digestive Diseases. Gastroenterology. 1456: 1600-1616
Lupino L, Perry T, Margielewska S, Hollows R, Ibrahim M, Care M, Allegood J, Tooze R, Sabbadini R, Reynolds G, Bicknell R, Rudzki Z, Lin Hock Y, Zanetto U, Wei W, Simmons W, Spiegel S, Woodman CBJ, Rowe M, Vrzalikova K, Murray PG, (2019). Sphingosine-1-phosphate signalling drives an angiogenic transcriptional programme in diffuse large B cell lymphoma. Leukemia. doi: 10.1038/s41375-019-0478-9. [Epub ahead of print]
Mayer D, Damberger FF, Samarasimhareddy M, Feldmueller M, Vuckovic Z, Flock T, Bauer B, Mutt E, Zosel F, Allain FHT, Standfuss J, Schertler GFX, Deupi X, Sommer ME, Hurevich M, Friedler A, Veprintsev DB,(2019). Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation. Nat Commun. 10 : 1261
Rayes J, Watson SP, Nueswandt B, (2019). Functional significance of the platelet immune receptors GPVI and CLEC-2. J Clin Invest. 129: 12-23
Shrine N, Guyatt AL, Erzurumluoglu AM, Jackson VE Hall IP et al, (2019). New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nat Genet. doi: 10.1038/s41588-019-0438-3. [Epub ahead of print]
Wand NO, Smith DA, Wilkinson AA, Rushton AE, Busby SJW, Styles IB, Neely RK, (2019). DNA barcodes for rapid, whole genome, single-molecule analyses. Nucleic Acids Res. pii: gkz212. doi: 10.1093/nar/gkz212. [Epub ahead of print]
Hollinshead KER, Munford H, Eales K, Bardella C, Li C, Escribano-Gonzalez C, Nonnenmacher Y, Thakker A, Murren R, Cuozzo F, Ye D, Laurenti G, Zhu W, Hiller K, Hodson DJ, Hua W, Tomlinson I, Ludwig C, Mao Y, Tennant, DA, (2018). Oncogenic IDH1 mutations promote enhanced proline synthesis through PYCR1 to support the maintenance of mitochondrial redox homeostasis. Cell Rep.
Geer MJ, van Geffen JP, Gopalasingam P, Vögtle T, Smith C, Heising S, Kuijpers MJE, Tullemans BME, Jarvis GE, Jeeves M, Overduin M, Heemskerk JWM, Mazharian A, Senis YA, (2018). Uncoupling of the ITIM receptor G6b-B from the tyrosine phosphatases Shp1 and Shp2 disrupts platelet homeostasis in mice. Blood. doi: 10.1182/blood-2017-10-802975. [Epub ahead of print]
Hofmann I, Geer MJ, Vögtle T, Crispin A, Campagna DR, Barr A, Calicchio ML, Heising S, van Geffen JP, Kuijper MJE, Heemskerk JWM, Schmitz-Abe K, Obeng EA, Douglas M, Freson K, Pondarré C, Favier R, Markianos K, Turro E, Ouwehand WH, Mazharian A, Fleming MD, Senis YA, (2018). Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice. Blood. doi: 10.1182/blood-2017-08-802769. [Epub ahead of print]
Mori J, Nagy Z, Di Nunzio G, Smith CW, Geer MJ, Al Ghaithi R, van Geffen JP, Heising S, Boothman L, Tullemans BME, Correia JN, Tee L, Kuijpers MJE, Harrison P, Heemskerk JWM, Jarvis GE, Tarakhovsky A, Weiss A, Mazharian A, Senis YA, (2018). Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148. Blood. 131: 1122-1144
Benninger RKP and Hodson DJ, (2018). New understanding of beta cell heterogeneity and in-situ islet function. Diabetes. 67:537-547
Beazley-Long N, Moss CE, Ashby WR, Bestall SM, Almahasneh F, Durrant AM, Benest AV, Blackley Z, Ballmer-Hofer K, Hirashima M, Hulse RP, Bates DO, Donaldson LF, (2018). VEGFR2 promotes central endothelial activation and the spread of pain in inflammatory arthritis. Brain, Behav & Imm (online)
Briddon SJ, Kilpatrick LE, Hill SJ, (2018). Studying GCPR pharmacology in membrane microdomains: Fluorescence Correlation Spectroscopy comes of age. Trends Pharmacol. Sci. (Review)
Rayes J, Lax S, Wichaiyo S, Watson SK, Di Y, Lombard S, Grygielska B, Smith SW, Skordilis K, Watson SP, (2017). The podoplanin-CLEC-2 axis inhibits inflammation in sepsis. Nat Commun 8: 2239
Sungkaworn T, Jobin ML, Burnecki K, Weron A, Lohse MJ, Calebiro D, (2017). Single-molecule imaging reveals receptor–G protein interactions at cell surface hot spots. Nature. 550: 543-547
Sykes DA, Moore H, Stott L, Holliday N, Javitch JA, Lane JR, Charlton SJ, (2017). Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors. Nat Commun. 8: 763
Ponomaryov T, Payne H, Fabrtz L, Wagner DD and Brill A, (2017). Mast cells granular contents are crucial for deep vein thrombosis in mice. Circ Res. 121: 941:950
Matthey M, Roberts R, Seidinger A, Simon A, Schroder R, Kuschak M, Annala S, Konig GM, Muller CE, Hall IP, Kostenis E, Fleischmann BK, Wenzel D, (2017). Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma. Sci Transl Med. 9 : 407
Botfield HF, Uldall MS, Westgate CSJ, Mitchell J, Hagen SM, Gonzalez A-M, Hodson DJ, Jensen RH, Sinclair AJ, (2017). A glucagon-like peptide-1 receptor agonist reduces intracranial pressure in a rat model of hydrocephalus. Sci Transl Med. 23: 9 (404)
Hobbs BD, de Jong K, Lamontagne M, Bossé Y, Shrine N, Artigas MS, Wain LV, Hall IP et al, (2017). Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat Genetics. 49: 426-432
Johnston NR, Mitchell RK, Haythorne E, Paiva Pessoa M, Semplici F, Ferrer J, Piemonti L, Marchetti P, Bugliani M, Bosco D, Berishvili E, Duncanson P, Watkinson, M, Broichhagen J, Trauner D, Rutter GA, Hodson DJ, (2016). Beta cell hubs dictate pancreatic islet responses to glucose. Cell Metab. 24: 389-401.
Frank JA, Yushchenko D, Hodson DJ, Lipstein N, Nagpal J, Rutter GA, Rhee J-S, Gottschalk A, Brose N, Schultz C, Trauner D, (2016). Photoswitchable diacylglycerols enable optical control of protein kinase C. Nat Chem Biol. 12: 755-62.