Fluorescence Approaches Unravel Spatial and Temporal Aspects of GPCR Organisation, Location, and Intracellular Signalling.

It is a great pleasure for us to introduce this special issue of Trends in Pharmacological Sciences outlining some of the new fluorescence and bioluminescence imaging approaches available to study cell-surface receptors [particularly G protein-coupled receptors (GPCRs)] in living cells. Detailed structural information has recently become available on GPCRs from both X-ray crystallography and cryoelectron microscopy. Evidence has also accumulated over the past few years to indicate that GPCRs may be organised into oligomeric complexes within the cell membrane.

The full article can be read found in Trends in Pharmaceutical Sciences, Volume 39, issue 2.