Seminar by Professor Ines Liebscher, Leipzip University  on 6th March at 12:00 

Targeting GPR133 – from orphan receptor to novel player in skeletal muscle and bone strength

Professor Liebsher will introduce the journey of deorphanising the adhesion GPCR GPR133 from first expression and signalling studies to the elucidation of a tethered agonist-mediated activation mechanism and the structural elucidation of this active receptor conformation. Her talk will further layout the different principles of endogenous activation for this receptor, which range from different N-terminal binders, mechanical forces to 5α-dihydrotestosterone and their physiological and pathophysiological implications. Finally, she will introduce the first specific and highly potent synthetic agonist for GPR133 and its potential to alleviate the disease burden in a postmenopausal osteoporosis mouse model.